You can use your Mac as the hub / interface of your MIDI synth setup without opening up your DAW. MIDIrouter is a free app that makes it simple to quickly set the MIDI In and Out ports.  
MIDIrouter
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Discussion

joost
Nice! Very handy. But so far I'm not able to open the app. It starts and then quits after a second.
eb0687
yea same issues here as well.

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